Systematic analysis of histone acetylation regulators across human cancers.

BACKGROUND: Histone acetylation (HA) is an important and common epigenetic pathway, which could be hijacked by tumor cells during carcinogenesis and cancer progression. However, the important role of HA across human cancers remains elusive. METHODS: In this study, we performed a comprehensive analysis at multiple levels, aiming to systematically describe the molecular characteristics and clinical relevance of HA regulators in more than 10000 tumor samples representing 33 cancer types. RESULTS: We found a highly heterogeneous genetic alteration landscape of HA regulators across different human cancer types. CNV alteration may be one of the major mechanisms leading to the expression perturbations in HA regulators. Furthermore, expression perturbations of HA regulators correlated with the activity of multiple hallmark oncogenic pathways. HA regulators were found to be potentially useful for the prognostic stratification of kidney renal clear cell carcinoma (KIRC). Additionally, we identified HDAC3 as a potential oncogene in lung adenocarcinoma (LUAD). CONCLUSION: Overall, our results highlights the importance of HA regulators in cancer development, which may contribute to the development of clinical strategies for cancer treatment.

Baicalin-liposomes loaded polyvinyl alcohol-chitosan electrospinning nanofibrous films: Characterization, antibacterial properties and preservation effects on mushrooms.

To investigate antibacterial properties and application in food preservation of nanofibrous films (NFs), baicalin-liposomes (BCL-LPs) were loaded into polyvinyl alcohol-chitosan (PVA-CS) substrates to form NFs using electrospinning technology. The microstructure and phase identification of the NFs were characterized. The antibacterial properties and cytotoxicity of NFs were determined. The preservation of the NFs to mushrooms was evaluated. The results showed that smooth and uniform NFs were formed through molecular interaction between BCL-LPs and PVA-CS matrix. The NFs exhibited good antibacterial effects on Escherichia coli and Staphylococcus aureus due to the bacterial destruction resulting from the BCL delivery to bacterial cells by liposomes. In addition, the NFs were compatible with L929 fibroblasts. The BCL-LPs/PVA-CS NFs inhibited weight loss, browning, rancidity and bacterial growth as well as maintained the nutrients of mushrooms. The results show BCL-LPs/PVA-CS NFs possessed effective antibacterial properties, non-cytotoxicity and preservation performance, indicating the potential utilization as food-active packing.

Controllable Chemoselectivity in Visible-Light Photoredox Catalysis: Four Diverse Aerobic Radical Cascade Reactions.

Reported is the controllable selectivity syntheses of four distinct products from the same starting materials by visible-light photoredox catalysis. By employing a dicyanopyrazine-derived chromophore (DPZ) as photoredox catalyst, an aerobic radical mechanism has been developed, and allows the reactions of N-tetrahydroisoquinolines (THIQs) with N-itaconimides to through four different pathways, including addition-cyclization, addition-elimination, addition-coupling, and addition-protonation, with satisfactory chemoselectivity. The current strategy provide straightforward access to four different but valuable N-heterocyclic adducts in moderate to excellent yields.

Highly enantioselective organocatalytic α-sulfenylation of azlactones.

The first asymmetric α-sulfenylation of azlactones with N-(sulfanyl)succinimides has been developed by using cinchona alkaloid-derived squaramide as a catalyst and 4 Å molecular sieves as an additive. The reaction conditions were suitable to 4-alkyl and benzyl-substituted azlactones as well as N-(benzyl/alkyl/arylthio)succinimides, affording adducts with high enantioselectivities (81-94% ee).

Manipulating graphene mobility and charge neutral point with ligand-bound nanoparticles as charge reservoir.

The high carrier mobility of graphene makes it an attractive candidate for future electronic device applications.(1) In SiO2/Si-supported graphene devices, the mobility typically varies from 2000 to ∼2,0000 cm(2) V(-1) s(-1).(2) By removing SiO2,(3,4) much higher mobility (2 × 10(5) cm(2) V(-1) s(-1) in the latter) has been obtained, suggesting the importance of the Coulomb scattering in graphene transport. Although such elaborate device fabrication is clearly effective, the mobility of finished devices is fixed thereafter and can vary from device to device. In this work, we first demonstrate a significant enhancement in carrier mobility in SiO2-supported graphene decorated with a layer of ligand-bound nanoparticles (NPs) such as iron oxide, titanium dioxide, or cadmium selenide acting as a charge reservoir. By transferring charges between graphene and the NP reservoir through the molecules, we show a remarkable reversible tunability in mobility (4000-19000 cm(2) V(-1) s(-1)) in the same device, which unambiguously proves that the charged impurity scattering is the prevailing mechanism for graphene mobility. In addition, the charge neutral point or the Dirac point can also be independently tuned over a wide gate voltage range. The reversible tuning is useful for fabricating large-area graphene devices such as nonvolatile memory with enhanced sensitivity.